Comparison of a reverse-transverse cross pin technique with a same side cross pin type II external skeletal fixator in 89 dogs

The objective of this study was to determine whether a novel reverse-transverse cross pin insertion technique could increase the stability of type II external skeletal fixators (ESF) in dogs compared with an alternate, same side cross pin ESF. Reverse-transverse cross pin technique and type II ESFs same side cross pin technique were applied and compared among subjects. Two of 42 ESFs (4.8%) applied with the reverse-transverse cross pin technique and 39 of 47 ESFs (83%) applied with the same side cross pin technique were subjectively unstable at the time of fixator removal (P < 0.001). The same side cross pin ESFs had significantly more pin tract new bone formation than the reverse-transverse ESFs (P = 0.038). In summary, this approach may provide a method of treating a variety of musculoskeletal conditions and soft tissue cases, which reverse-transverse cross pin ESFs are tolerated in dogs for a variety of conditions

Nivolumab plus ipilimumab in the treatment of advanced melanoma.

Advanced melanoma has historically been a difficult disease to treat due to few effective systemic treatment options. However, over the past few years, scientific advancements in immune checkpoint inhibition have resulted in several novel approaches that have changed front-line management of advanced melanoma. Despite these exciting developments, there remains room for improvement in treatment outcomes. Combination immunotherapy, in particular combined cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) blockade, represents an important first step in this direction

Global dispersive solutions for the Gross-Pitaevskii equation in two and three dimensions

We study asymptotic behaviour at time infinity of solutions close to the non-zero constant equilibrium for the Gross-Pitaevskii equation in two and three spatial dimensions. We construct a class of global solutions with prescribed dispersive asymptotic behavior, which is given in terms of the linearized evolution

Renormalization group approach to spinor Bose-Fermi mixtures in a shallow optical lattice

We study a mixture of ultracold spin-half fermionic and spin-one bosonic atoms in a shallow optical lattice where the bosons are coupled to the fermions via both density-density and spin-spin interactions. We consider the parameter regime where the bosons are in a superfluid ground state, integrate them out, and obtain an effective action for the fermions. We carry out a renormalization group analysis of this effective fermionic action at low temperatures, show that the presence of the spinor bosons may lead to a separation of Fermi surfaces of the spin-up and spin-down fermions, and investigate the parameter range where this phenomenon occurs. We also calculate the susceptibilities corresponding to the possible superfluid instabilities of the fermions and obtain their possible broken-symmetry ground states at low temperatures and weak interactions.Comment: 8 pages, 8 figs v

Critical Entanglement for the Half-Filled Extended Hubbard Model

We study the ground state of the one-dimensional extended Hubbard model at half-filling using the entanglement entropy calculated by Density Matrix Renormalization Group (DMRG) techniques. We apply a novel curve fitting and scaling method to accurately identify a $2^{nd}$ order critical point as well as a Berezinskii-Kosterlitz-Thouless (BKT) critical point. Using open boundary conditions and medium-sized lattices with very small truncation errors, we are able to achieve similar accuracy to previous authors. We also report observations of finite-size and boundary effects that can be remedied with careful pinning.Comment: 10 pages, 12 figure

Dominant Superconducting Fluctuations in the One-Dimensional Extended Holstein-Extended Hubbard model

The search for realistic one-dimensional (1D) models that exhibit dominant superconducting (SC) fluctuations effects has a long history. In these 1D systems, the effects of commensurate band fillings--strongest at half-filling--and electronic repulsions typically lead to a finite charge gap and the favoring of insulating density wave ordering over superconductivity. Accordingly, recent proposals suggesting a gapless metallic state in the Holstein-Hubbard (HH) model, possibly superconducting, have generated considerable interest and controversy, with the most recent work demonstrating that the putative dominant superconducting state likely does not exist. In this paper we study a model with non-local electron-phonon interactions, in addition to electron-electron interactions, this model unambiguously possesses dominant superconducting fluctuations at half filling in a large region of parameter space. Using both the numerical multi-scale functional renormalization group for the full model and an analytic conventional renormalization group for a bosonized version of the model, we demonstrate the existence of dominant superconducting (SC) fluctuations. These dominant SC fluctuations arise because the spin-charge coupling at high energy is weakened by the non-local electron-phonon interaction and the charge gap is destroyed by the resultant suppression of the Umklapp process. The existence of the dominant SC pairing instability in this half-filled 1D system suggests that non-local boson-mediated interactions may be important in the superconductivity observed in the organic superconductors.Comment: 8 pages, 4 figure

Functional renormalization group analysis of the half-filled one-dimensional extended Hubbard model

We study the phase diagram of the half-filled one-dimensional extended Hubbard model at weak coupling using a novel functional renormalization group (FRG) approach. The FRG method includes in a systematic manner the effects of the scattering processes involving electrons away from the Fermi points. Our results confirm the existence of a finite region of bond charge density wave, also known as a "bond order wave" near U=2V and clarify why earlier g-ology calculations have not found this phase. We argue that this is an example in which formally irrelevant corrections change the topology of the phase diagram. Whenever marginal terms lead to an accidental symmetry, this generalized FRG method may be crucial to characterize the phase diagram accurately.First author draf

Renormalization-group approach to superconductivity: from weak to strong electron-phonon coupling

We present the numerical solution of the renormalization group (RG) equations derived in Ref. [1], for the problem of superconductivity in the presence of both electron-electron and electron-phonon coupling at zero temperature. We study the instability of a Fermi liquid to a superconductor and the RG flow of the couplings in presence of retardation effects and the crossover from weak to strong coupling. We show that our numerical results provide an ansatz for the analytic solution of the problem in the asymptotic limits of weak and strong coupling.Comment: 8 pages, 3 figures, conference proceedings for the Electron Correlations and Materials Properties, in Kos, Greece, July 5-9, 200